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Article

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.

The Journal of biological chemistry - 7 Oct 2005

Petit Agnes, Kawarai Toshitaka, Paitel Erwan, Sanjo Nobuo, Maj Mary, Scheid Michael, Chen Fusheng, Gu Yongjun, Hasegawa Hiroshi, Salehi-Rad Shabnam, Wang Linda, Rogaeva Ekaterina, Fraser Paul, Robinson Brian, St George-Hyslop Peter, Tandon Anurag

Abstract excerpt

Mutations in the PTEN-induced kinase 1 (PINK1) gene have recently been implicated in autosomal recessive early onset Parkinson Disease (1, 2). To investigate the role of PINK1 in neurodegeneration, we designed human and murine neuronal cell lines expressing either wild-type PINK1 or PINK1 bearing...

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Source

Identifiers

PMID: 16079129
DOI: 10.1074/jbc.M505143200

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16079129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.PMID 16079129Read ↗

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