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Article

The micro1 gene is necessary and sufficient for micromere differentiation and mid/hindgut-inducing activity in the sea urchin embryo.

Development genes and evolution - 1 Sept 2005

Yamazaki Atsuko, Kawabata Rika, Shiomi Kosuke, Amemiya Shonan, Sawaguchi Masaya, Mitsunaga-Nakatsubo Keiko, Yamaguchi Masaaki

Abstract excerpt

In the sea urchin embryo, micromeres have two distinct functions: they differentiate cell autonomously into the skeletogenic mesenchyme cells and act as an organizing center that induces endomesoderm formation. We demonstrated that micro1 controls micromere specification as a transcriptional repressor. Because micro1 is a multicopy gene with at least six polymorphic loci, it has been difficult to consistently...

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PMID: 16078091
DOI: 10.1007/s00427-005-0006-y

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