Article
Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation.
Leukemia research - 1 Jan 2006
Hemavathy Kirugaval C, Chang Tsong H, Zhang Haowei, Charles William, Goldberg Amit, Aithal Sramila, Novetsky Allan D, Wang Jen C
Abstract excerpt
Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis and enhanced proliferation of megakaryocytes and CD34+ cells. We have analyzed the factors that could lead to reduced expression of TGF beta1RII in CD34+ cells of AMM patients. Our results demonstrate absence of mutations in the coding region and the promoter of this gene and absence of CpG methylation of its promoter in AMM patients....
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