[Genetic abnormalities underlying formation of choroidal melanoma].

Abstract excerpt

Genetic mechanisms underlying formation of ocular and skin melanoma differ in many aspects, the former being still poorly understood. It has been suggested that choroidal melanoma can develop due to accumulation of genetic alterations in the DNA of normal melanocytes. Neoplastic transformation in the choroid can be triggered as a consequence of the following genetic alterations: --deletions and/or amplifications...

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