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Article

Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations.

Biophysical journal - 16 Feb 2011

Bai Fan, Weis Adam, Takeda Aya K, Chase P Bryant, Kawai Masataka

Abstract excerpt

Three HCM-causing tropomyosin (Tm) mutants (V95A, D175N, and E180G) were examined using the thin-filament extraction and reconstitution technique. The effects of Ca(2+), ATP, phosphate, and ADP concentrations on cross-bridge kinetics in myocardium reconstituted with each of these mutants were studied at 25°C, and compared to wild-type (WT) Tm at physiological ionic strength (200 mM). All three mutants showed...

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Identifiers

PMID: 21320446
DOI: 10.1016/j.bpj.2011.01.001
PMCID: PMC3037557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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