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Article

New genotype-phenotype linkages for directed evolution of functional proteins.

Current opinion in structural biology - 1 Aug 2005

Leemhuis Hans, Stein Viktor, Griffiths Andrew D, Hollfelder Florian

Abstract excerpt

The key practical consideration in directed evolution of functional biomolecules is the linkage of genotype and phenotype. In vitro selections offer the potential to select from libraries with up to 10(10)-10(14) members, with fewer constraints than current cell-based selections. New approaches such as mRNA display, ribosome display and in vitro compartmentalisation have complementary areas of application in...

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Identifiers

PMID: 16043338
DOI: 10.1016/j.sbi.2005.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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