Article
Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia.
Journal of psychiatric research - 1 Oct 2006
Zammit Stanley, Lewis Glyn, Thapar Anita, Owen Richard, Jones Gaynor, Jones Susan, Sanders Rob, Milham Charis, Mahdi Ameera, O'Donovan Michael C, Owen Michael J
Abstract excerpt
BACKGROUND: Phenotypic differences between parent-offspring trios and non-trios have been reported for various psychiatric disorders, and it has been suggested that this may make comparisons of case-control and family-based results for gene-disease association studies inappropriate. AIMS: To compare phenotypes between trios and non-trios with schizophrenia, and explore possible reasons for differences observed....
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