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Article

Inhibition of glutamine synthetase triggers apoptosis in asparaginase-resistant cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2005

Rotoli Bianca Maria, Uggeri Jacopo, Dall'Asta Valeria, Visigalli Rossana, Barilli Amelia, Gatti Rita, Orlandini Guido, Gazzola Gian C, Bussolati Ovidio

Abstract excerpt

The resistance to L-asparaginase (ASNase) has been associated to the overexpression of asparagine synthetase (AS), although the role played by other metabolic adaptations has not been yet defined. Both in ASNase-sensitive Jensen rat sarcoma cells and in ARJ cells, their ASNase-resistant counterparts endowed with a five-fold increased AS activity, ASNase treatment rapidly depletes intracellular asparagine. Under...

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PMID: 16037693
DOI: 10.1159/000087238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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