Article
HLA class I null alleles and new alleles affect unrelated bone marrow donor searches.
Tissue antigens - 1 Aug 2005
Smith D M, Baker J E, Gardner W B, Martens G W, Agura E D
Abstract excerpt
Unrecognized HLA null alleles or new alleles may affect the outcome of bone marrow transplants using unrelated donors. Some reports suggest that null alleles occur in the range of 0.003-0.07% (1, 2), which has led some transplant programs to stop performing serologic typing. We describe nine cases involving expression variants or new alleles. Three cases involved expression variants, including two null alleles...
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