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Article

Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans.

Nucleic acids research - 1 Jan 2005

Landers Miguel, Calciano Margaret A, Colosi Dan, Glatt-Deeley Heather, Wagstaff Joseph, Lalande Marc

Abstract excerpt

Angelman syndrome (AS) is a neurogenetic disorder characterized by severe mental retardation, 'puppet-like' ataxic gait with jerky arm movements, seizures, EEG abnormalities, hyperactivity and bouts of inappropriate laughter. Individuals with AS fail to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (UBE3A). UBE3A is transcribed predominantly from the maternal allele in...

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Identifiers

PMID: 16027444
DOI: 10.1093/nar/gki705
PMCID: PMC1178004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans.PMID 16027444Read ↗

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