Article
Do alpha deletions influence hydroxyurea response in thalassemia intermedia?
Hematology (Amsterdam, Netherlands) - 1 Feb 2005
Panigrahi I, Dixit A, Arora S, Kabra M, Mahapatra M, Choudhry V P, Saxena R
Abstract excerpt
Thalassemia intermedia patients show variable phenotypes. Hydroxyurea (HU) may benefit some of the thalassemia intermedia cases (1), however, the parameters influencing the response to HU have not been reported. In this study, the molecular parameters, alpha-globin and beta-globin genotype and the Xmn I polymorphism, were correlated with the HU response. Twenty patients with thalassemia intermedia were given HU...
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