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Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics

6 Jul 2005

Abstract excerpt

To delineate multiple myeloma (MM) subgroups and their clonal evolution, we analyzed 81 newly diagnosed patients by interphase fluorescence in situ hybridization using a comprehensive probe set for 10 chromosomes and two IGH rearrangements. A median of 5 probes per patient displayed aberrant signal numbers (range, 1-10). Additional copies most frequently found were for 15q22, 19q13, 9q34, 11q23, and 1q21. Losses...

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PMID: 16001433
DOI: 10.1002/gcc.20231

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