Article
A haplotype analysis of HER-2 gene polymorphisms: association with breast cancer risk, HER-2 protein expression in the tumor, and disease recurrence in Korea.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2005
Han Wonshik, Kang Daehee, Lee Jong Eun, Park In Ae, Choi Ji-Yeob, Lee Kyung-Mu, Bae Ji Yeon, Kim Sook, Shin Eun-Soon, Lee Jeong Eon, Shin Hyuk-Jae, Kim Seok Won, Kim Sung-Won, Noh Dong-Young
Abstract excerpt
PURPOSE: A single-nucleotide polymorphism (SNP) in codon 655 of HER-2 has been extensively studied with inconclusive results. The purpose of this study was to investigate the association between common variants of HER-2 and breast cancer risk, HER-2 expression, and survival using a haplotype-based stepwise approach. EXPERIMENTAL DESIGN: Twenty-nine SNPs listed in the National Center for Biotechnology Information...
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