Article
Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Anishchenko Michael, Bowen Richard A, Paessler Slobodan, Austgen Laura, Greene Ivorlyne P, Weaver Scott C
Abstract excerpt
RNA viruses are notorious for their genetic plasticity and propensity to exploit new host-range opportunities, which can lead to the emergence of human disease epidemics such as severe acute respiratory syndrome, AIDS, dengue, and influenza. However, the mechanisms of host-range change involved in most of these viral emergences, particularly the genetic mechanisms of adaptation to new hosts, remain poorly...
Topics
- Amino Acids
- Animals
- Antibodies, Monoclonal
- Encephalitis Virus, Venezuelan Equine
- Encephalomyelitis, Venezuelan Equine
- Horses
- Mice
- Mutation
- Phylogeny