Article
Association between glaucoma and gene polymorphism of endothelin type A receptor.
Molecular vision - 23 Jun 2005
Ishikawa Karin, Funayama Tomoyo, Ohtake Yuichiro, Kimura Itaru, Ideta Hidenao, Nakamoto Kenji, Yasuda Noriko, Fukuchi Takeo, Fujimaki Takuro, Murakami Akira, Asaoka Ryo, Hotta Yoshihiro, Kanamoto Takashi, Tanihara Hidenobu, Miyaki Koichi, Mashima Yukihiko
Abstract excerpt
PURPOSE: Endothelin 1 (ET-1), a potent vasoconstrictor, may affect regulation of intraocular pressure and ocular vessel tone. Thus, ET-1 and its receptors may contribute to development of glaucoma. We investigated whether gene polymorphisms of ET-1 (EDN1) and its receptors ETA (EDNRA) and ETB (EDNRB) were associated with glaucoma phenotypes and clinical features. METHODS: We studied 224 normal Japanese controls...
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