Article
[Laminopathies: lipodystrophies, insulin resistance, syndromes of accelerated ageing... and others].
Annales d'endocrinologie - 1 Jun 2005
Vigouroux C
Abstract excerpt
Laminopathies are a group of diseases due to mutations of type A-lamins, a group of proteins lining the inner aspect of cell nuclei. These diseases illustrate the complexity of the genotype-phenotype relationship characteristic of same genetic diseases. Since the discovery of the causal role of LMNA gene mutations in the genesis of Emery Dreifuss muscular dystrophy in 1999, no less than eight other diseases have...
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