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Article

Molecular analysis of a congenital iodide transport defect: G543E impairs maturation and trafficking of the Na+/I- symporter.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2005

De la Vieja Antonio, Ginter Christopher S, Carrasco Nancy

Abstract excerpt

The Na+/I- symporter (NIS) is a key membrane glycoprotein that mediates active I- transport in the thyroid and other tissues. Upon isolation of the cDNA encoding NIS, 10 NIS mutations that cause congenital iodide transport defect have been identified. Three of these mutations (T354P, G395R, and Q267E) have been thoroughly characterized at the molecular level. All three NIS mutant proteins are correctly targeted...

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PMID: 15976004
DOI: 10.1210/me.2005-0162

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Molecular analysis of a congenital iodide transport defect: G543E impairs maturation and trafficking of the Na+/I- symporter.PMID 15976004Read ↗

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