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Article

SigB Is a Dominant Regulator of Virulence in Staphylococcus aureus Small-Colony Variants

21 May 2013

Abstract excerpt

Staphylococcus aureus small-colony variants (SCVs) are persistent pathogenic bacteria characterized by slow growth and, for many of these strains, an increased ability to form biofilms and to persist within host cells. The virulence-associated gene expression profile of SCVs clearly differs from that of prototypical strains and is often influenced by SigB rather than by the agr system. One objective of this work...

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PMID: 23705029
DOI: 10.1371/journal.pone.0065018

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