Article
Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law.
Behavioural pharmacology - 1 Jul 2005
Sanchis-Segura C, Spanagel R, Henn F A, Vollmayr B
Abstract excerpt
Anhedonia is a core symptom of depression. As it cannot be directly assessed in rodents, anhedonia is usually inferred from a reduced consumption of, or preference for, a reinforcer. In the present study we tried to improve the measurement of anhedonia by performing a detailed preference analysis based on the generalized matching law and tested its sensitivity in rats congenitally prone (cLH) or resistant (cNLH)...
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