Article
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting,during a critical developmental period
16 Jun 2005
Abstract excerpt
Early in development, endothelial cells proliferate, coalesce, and sprout to form a primitive plexus of undifferentiated microvessels. Subsequently, this plexus remodels into a hierarchical network of different-sized vessels. Although the processes of proliferation and sprouting are well studied and are dependent on the angiogenic growth factor VEGF, the factors involved in subsequent vessel remodeling are poorly...
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