Article
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells.
Virology - 20 Jul 2008
Volkova Eugenia, Frolova Elena, Darwin Justin R, Forrester Naomi L, Weaver Scott C, Frolov Ilya
Abstract excerpt
The development of infectious cDNA for different alphaviruses opened an opportunity to explore their attenuation by extensively modifying the viral genomes, an approach that might minimize or exclude the reversion to the wild-type, pathogenic phenotype. Moreover, the genomes of such alphaviruses can be engineered to contain RNA elements that would be functional only in cells of vertebrate, but not insect, origin....
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