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Article

A Cellular Homolog of Hepatitis Delta Antigen: Implications for Viral Replication and Evolution

4 Oct 1996

Abstract excerpt

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. However, viroid genomes contain no open reading frames, whereas HDV RNA encodes a single protein, hepatitis delta antigen (HDAg), which is required for viral replication. A cellular gene whose product interacts with HDAg has now been identified, and this interaction was found to affect...

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PMID: 8810253
DOI: 10.1126/science.274.5284.90

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