Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.

Blood - 1 Oct 2005

Chen Xin, Murakami Takaya, Oppenheim Joost J, Howard O M Zack

Abstract excerpt

Triptolide (TPT) is a chemically defined, potent immunosuppressive compound isolated from an anti-inflammatory Chinese herbal medicine. TPT has been reported to inhibit autoimmunity, allograft rejection, and graft-versus-host disease (GVHD), and its efficacy was previously attributed to the suppression of T cells. Since dendritic cells (DCs) play a major role in the initiation of T-cell-mediated immunity, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokines, CC
Share to Diterpenes
Share to Drugs, Chinese Herbal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epoxy Compounds

Share to Fluorescein-5-isothiocyanate

Share to Interleukin-12

Share to Langerhans Cells

Share to Phenanthrenes

Source

Open in PubMed Open full text

Identifiers

PMID: 15956285
DOI: 10.1182/blood-2005-03-0854
PMCID: PMC1569904

Genes

CCL19
CCL21
CCR5
CCR7
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.PMID 15956285Read ↗

Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells.Semantic proximity Read ↗

Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.Semantic proximity Read ↗

A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines.Semantic proximity Read ↗

Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells.Semantic proximity Read ↗

Handbook of experimental pharmacology "dendritic cells": the use of dexamethasone in the induction of tolerogenic DCs.Semantic proximity Read ↗

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.Semantic proximity Read ↗

A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE.Semantic proximity Read ↗

Inhibition of generation of cytotoxic T lymphocyte activity by a CCL19/macrophage inflammatory protein (MIP)-3beta antagonist.Semantic proximity Read ↗

Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant.Semantic proximity Read ↗

Standardized extracts from Chinese herbs induce IL-10 production in human monocyte-derived dendritic cells and alter their differentiation in vitro.Semantic proximity Read ↗

Effect of phenylethanoid glycosides and polysaccharides from the seed of Plantago asiatica L. on the maturation of murine bone marrow-derived dendritic cells.Semantic proximity Read ↗

Comparative study of clinical grade human tolerogenic dendritic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.