Article
Fluoroquinolone treatment of experimental Salmonella enterica serovar Typhimurium DT104 infections in chickens selects for both gyrA mutations and changes in efflux pump gene expression.
The Journal of antimicrobial chemotherapy - 1 Aug 2005
Randall Luke P, Eaves Deborah J, Cooles Sue W, Ricci V, Buckley Antony, Woodward Martin J, Piddock Laura J V
Abstract excerpt
OBJECTIVES: To determine the efficacy of enrofloxacin (Baytril) in chickens in eradicating three different resistance phenotypes of Salmonella enterica and to examine the resistance mechanisms of resulting mutants. METHODS: In two separate replicate experiments (I and II), three strains of Salmonella enterica serovar Typhimurium DT104 [strain A, fully antibiotic-sensitive strain; strain B, isogenic multiple...
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