Article
Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.
Antimicrobial agents and chemotherapy - 1 Sept 1999
Giraud E, Brisabois A, Martel J L, Chaslus-Dancla E
Abstract excerpt
The occurrence of mutations in the genes coding for gyrase (gyrA and gyrB) and topoisomerase IV (parE and parC) of Salmonella typhimurium experimental mutants selected in vitro and in vivo and of 138 nalidixic acid-resistant Salmonella field isolates was investigated. The sequencing of the quinolone resistance-determining region of these genes in highly fluoroquinolone-resistant mutants (MICs of 4 to 16...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.