Article
Quantitative analysis of tau isoform transcripts in sporadic tauopathies.
Brain research. Molecular brain research - 13 Jun 2005
Connell J W, Rodriguez-Martin T, Gibb G M, Kahn N M, Grierson A J, Hanger D P, Revesz T, Lantos P L, Anderton B H, Gallo J-M
Abstract excerpt
A number of neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by intraneuronal accumulation of the tau protein. Some forms of FTDP-17 are caused by mutations in the tau gene affecting exon 10 splicing. Therefore, dysregulation of tau pre-mRNA splicing may be a cont...
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