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Article

Preservation of phenotype in an organotypic cell culture model of a recessive keratinization defect of Norfolk terrier dogs.

Experimental dermatology - 1 Jul 2005

Barnhart Kirstin F, Credille Kelly M, Ambrus Andy, Dunstan Robert W

Abstract excerpt

The purpose of this study is to reproduce in vitro a recessive keratinization defect of Norfolk terrier dogs characterized by a lack of keratin 10 (K10) production. Keratinocytes from skin biopsy samples of four normal dogs and two affected dogs were cultured organotypically with growth factor-supplemented media in order to stimulate cornification. The cultured epidermis from the normal dogs closely resembled the...

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Identifiers

PMID: 15946235
DOI: 10.1111/j.0906-6705.2005.00306.x

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