Article
[Clinical and molecular correlation between chronic hepatitis and hepatocellular carcinoma induced by hepatitis B virus].
Arkhiv patologii - 1 Jan 2000
Shapiro I Ia, Shabrov A V, Karev V E, Leenman E E, Kvetnoĭ I M, Tsinzerling V A, Sologub T V
Abstract excerpt
The role of X-gene of hepatitis B virus (HBV), telomerase gene, structural HBV proteins is considered. Both factors of the virus and those of the host are involved in hepatocarcinogenesis. The duration of chronic B hepatitis may influence mitogenic and mutagenic conditions for accumulation of occasional genetic and chromosomal damage and result in hepatocarcinoma development.
Topics
- Animals
- Carcinoma, Hepatocellular
- Cell Proliferation
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms
- Mutation
- Telomerase
- Trans-Activators
- Tumor Suppressor Protein p53