Article
Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.
Molecular vision - 12 May 2005
Martin Rex E, Fliesler Steven J, Brush Richard S, Richards Michael J, Hopkins Stephen A, Anderson Robert E
Abstract excerpt
PURPOSE: Retinal degenerations and diets low in n-3 fatty acids are associated with decreased docosahexaenoic acid (22:6n-3) in retina and plasma and with sterol abnormalities in retina and sperm. Using wild type (WT) and transgenic rats with P23H and S334ter opsin mutations, we evaluated retinal cholesterol levels, cholesterol synthesis, and fatty acid compositions of phospholipid classes in animals fed diets...
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