Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.

doi:10.1002/ajmg.b.30196

Article

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005

Martinez Maria, Brice Alexis, Vaughan Jenny R, Zimprich Alexander, Breteler Monique M B, Meco Giuseppe, Filla Alessandro, Farrer Matthew J, Bétard Christine, Singleton Andrew, Hardy John, De Michele Giuseppe, Bonifati Vincenzo, Oostra Ben A, Gasser Thomas, Wood Nick W, Dürr Alexandra

Abstract excerpt

Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.

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