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Article

Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation.

The Journal of biological chemistry - 15 Jul 2005

Choi Mal-Gi, Kurnov Vladlen, Kersting Michael C, Sreenivas Avula, Carman George M

Abstract excerpt

The Saccharomyces cerevisiae CKI1-encoded choline kinase catalyzes the committed step in phosphatidylcholine synthesis via the Kennedy pathway. The enzyme is phosphorylated on multiple serine residues, and some of this phosphorylation is mediated by protein kinase A. In this work we examined the hypothesis that choline kinase is also phosphorylated by protein kinase C. Using choline kinase as a substrate, protein...

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Biochemical Phenomena
Biochemistry
Cyclic AMP-Dependent Protein Kinases
Hydrolysis
Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Mapping

Phosphatidylcholines

Protein Kinase C

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PMID: 15919656
DOI: 10.1074/jbc.M503551200
PMCID: PMC1383591

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