Article
Neuroprotection by KATP channels.
Journal of molecular and cellular cardiology - 1 Jun 2005
Yamada Katsuya, Inagaki Nobuya
Abstract excerpt
The substantia nigra pars reticulata, the area with the highest expression of ATP-sensitive potassium channels in the brain, plays a pivotal role in suppressing the propagation of generalized seizures by its silence. Mice lacking the Kir6.2 subunit of the channels were extremely susceptible to generalized seizures after brief hypoxia. The nigral neuron activity, which is among highest in the brain, was rapidly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
