Article
Decreased virulence of a gls24 mutant of Enterococcus faecalis OG1RF in an experimental endocarditis model.
Infection and immunity - 1 Nov 2005
Nannini Esteban C, Teng Fang, Singh Kavindra V, Murray Barbara E
Abstract excerpt
In the current study, the gls24 disruption mutant TX10100, previously shown to be more sensitive to bile salts and attenuated in a mouse peritonitis model, showed an approximately fivefold higher 50% infective dose than wild-type OG1RF in a rat endocarditis model. When administered as a mixture, TX10100, unlike a downstream glsB mutant, was significantly outnumbered by OG1RF in vegetations, organs, and blood,...
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