Article
Morphological differences in cardiovascular anomalies induced by bis-diamine between Sprague-Dawley and Wistar rats.
Congenital anomalies - 1 Jun 2005
Fujino Hidetoshi, Nakagawa Masao, Nishijima Setsuko, Okamoto Nobuhiko, Hanato Takashi, Watanabe Noriko, Shirai Takeaki, Kamiya Hiroshi, Takeuchi Yoshihiro
Abstract excerpt
It is known that animals show different responses to the same teratogen between different strains. We examined cardiac malformations in Sprague-Dawley (SD) and Wistar rats induced by bis-diamine, which produced conotruncal anomalies and aortic arch malformations in embryos when administered to the dams, to elucidate the morphological differences and pathogenesis in the two strains. Two hundred milligrams of...
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