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Article

Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development

30 Oct 2007

Abstract excerpt

BACKGROUND: Congenital heart defects are frequently observed in infants of diabetic mothers, but the molecular basis of the defects remains obscure. Thus, the present study was performed to gain some insights into the molecular pathogenesis of maternal diabetes-induced congenital heart defects in mice. METHODS AND RESULTS: We analyzed the morphological changes, the expression pattern of some genes, the...

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PMID: 17967198
DOI: 10.1186/1475-2840-6-34

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