Article
Strain variability in Zucker rats affects their response to oral oleoyl-estrone.
Diabetes, nutrition & metabolism - 1 Dec 2004
Díaz-Silva M, Grasa M M, Blay M, Fernández-López J A, Remesar X, Alemany M
Abstract excerpt
There is a considerable variability in the responses of Zucker fa/fa rats in metabolic studies, which could not be solely attributed to the leprfa mutation. In order to fathom the extent of this variability, we compared the response to oleoyl-estrone (OE), a powerful lipid-mobilising agent, of two strains of Zucker lean and obese rats: Harlan (H) and Charles River (CR). Rats were given an oral gavage of 10...
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