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Article

Substrate-induced tryptophan fluorescence changes in EmrE, the smallest ion-coupled multidrug transporter.

Biochemistry - 17 May 2005

Elbaz Yael, Tayer Naama, Steinfels Emmanuelle, Steiner-Mordoch Sonia, Schuldiner Shimon

Abstract excerpt

Tryptophan residues may play several roles in integral membrane proteins including direct interaction with substrates. In this work we studied the contribution of tryptophan residues to substrate binding in EmrE, a small multidrug transporter of Escherichia coli that extrudes various positively charged drugs across the plasma membrane in exchange with protons. Each of the four tryptophan residues was replaced by...

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PMID: 15882076
DOI: 10.1021/bi050356t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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