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Article

An <i>LRRK2</i> mutation as a cause for the parkinsonism in the original <i>PARK8</i> family

4 May 2005

Abstract excerpt

We detected a missense mutation in the kinase domain of the LRRK2 gene in members with autosomal dominant Parkinson's disease of the Japanese family (the Sagamihara family) who served as the basis for the original defining of the PARK8 Parkinson's disease locus. The results of the Sagamihara family, in combination with the unique pathological features characterized by pure nigral degeneration without Lewy bodies,...

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PMID: 15880653
DOI: 10.1002/ana.20484

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