Article
Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas.
International journal of cancer - 20 Oct 2005
Schüller Ulrich, Koch Arend, Hartmann Wolfgang, Garrè Maria L, Goodyer Cynthia G, Cama Armando, Sörensen Niels, Wiestler Otmar D, Pietsch Torsten
Abstract excerpt
Recent findings indicate that the chemokine receptor Cxcr4 is essential for normal development of the cerebellar cortex. As medulloblastomas (MBs), the most common malignant brain tumors of childhood, are believed to arise from neuronal cerebellar precursors, we asked whether there is a potential role for Cxcr4 in the pathogenesis of MB. RT-PCR and immunohistochemistry revealed expression of Cxcr4 in different...
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