Article
Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma.
Familial cancer - 1 Oct 2016
Kruizinga Roeliene C, van Marion Denise M S, den Dunnen Wilfred F A, de Groot Jan C, Hoving Eelco W, Oosting Sjoukje F, Timmer-Bosscha Hetty, Derks Rosalie P H, Cornelissen Chantal, van der Luijt Rob B, Links Thera P, de Vries Elisabeth G E, Walenkamp Annemiek M E
Abstract excerpt
Central nervous system hemangioblastomas occur sporadically and in patients with von Hippel-Lindau (VHL) disease due to a VHL germline mutation. This mutation leads to enhanced transcription of chemokine receptor 4 (CXCR4), its ligand (CXCL12) and vascular endothelial growth factor A (VEGFA). We aimed to determine in VHL-related and sporadic hemangioblastomas CXCR4, CXCL12, and VEGFA protein expression and to...
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