Article
Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 May 2005
Luo Shengyuan, Cassidy William, Jeffers Lennox, Reddy K Rajender, Bruno Christine, Howell Charles D
Abstract excerpt
BACKGROUND & AIMS: Black American patients are less likely to eradicate hepatitis C virus (HCV) infections during treatment with peginterferon (PEG-IFN) and ribavirin. We hypothesized that racial differences in IFN-stimulated antiviral gene induction during treatment might be responsible. METHODS: We examined myxovirus resistance-A (MxA), RNA-dependent protein kinase (PKR), 2'-5' oligoadenylate synthetase...
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