Article
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2005
Silva Elisabeth M, Guillermo Landi V C, Ribeiro-Gomes Flávia L, De Meis Juliana, Pereira Renata M S, Wu Zhengqi, Calegari-Silva Teresa C, Seabra Sérgio H, Lopes Ulisses G, Siegel Richard M, Dosreis George A, Lopes Marcela F
Abstract excerpt
During Trypanosoma cruzi infection, T cells up-regulate caspase-8 activity. To assess the role of caspase-8 in T cell-mediated immunity, we investigated the effects of caspase-8 inhibition on T cells in viral FLIP (v-FLIP) transgenic mice. Compared with wild-type controls, increased parasitemia was observed in v-FLIP mice infected with T. cruzi. There was a profound decrease in expansion of both CD4 and CD8 T...
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