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Article

Differential termination of primer extension: a novel, quantifiable method for detection of point mutations.

Human genetics - 1 May 1992

Picketts D J, Cameron C, Taylor S A, Deugau K V, Lillicrap D P

Abstract excerpt

We have developed a novel technique that is useful for the rapid detection of previously characterized point mutations in the human genome. The method relies on the differential termination of primer extension being performed simultaneously on normal and mutant template molecules in the presence of a selectively limited complement of deoxynucleotide triphosphates. We have used this technique to determine the...

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PMID: 1587524
DOI: 10.1007/BF00217115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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