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Article

Unstable Vancomycin Heteroresistance Is Common among Clinical Isolates of Methiciliin-Resistant <i>Staphylococcus aureus</i>

1 May 2005

Abstract excerpt

We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical...

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PMID: 15872293
DOI: 10.1128/jcm.43.5.2494-2496.2005

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