Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Periocular Gene Transfer of Pigment Epithelium-Derived Factor Inhibits Choroidal Neovascularization in a Human-Sized Eye

1 Apr 2005

Abstract excerpt

Gene transfer provides a potential way to achieve sustained delivery of therapeutic proteins to the eye. Studies in rodents have suggested that periocular injection of adenoviral vectors containing expression cassettes for antiangiogenic proteins results in high intraocular levels of the proteins and suppression of choroidal neovascularization (CNV). However, the differences in size and scleral thickness between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15871678
DOI: 10.1089/hum.2005.16.473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Periocular Gene Transfer of Pigment Epithelium-Derived Factor Inhibits Choroidal Neovascularization in a Human-Sized EyePMID 15871678Read ↗

Periocular injection of an adenoviral vector encoding pigment epithelium-derived factor inhibits choroidal neovascularizationSemantic proximity Read ↗

Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene TherapySemantic proximity Read ↗

Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal modelSemantic proximity Read ↗

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 PlasmidsSemantic proximity Read ↗

Gene transfer for ocular neovascularization and macular edemaSemantic proximity Read ↗

Viral-Vector Delivered anti-Angiogenic Therapies to the EyeSemantic proximity Read ↗

AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expressionSemantic proximity Read ↗

Inhibition of Choroidal Neovascularization via Brief Subretinal Exposure to a Newly Developed Lentiviral Vector Pseudotyped with Sendai Viral Envelope ProteinsSemantic proximity Read ↗

Inhibition of Retinal Neovascularization by Intraocular Viral-Mediated Delivery of Anti-angiogenic AgentsSemantic proximity Read ↗

Placental Growth Factor, a Member of the VEGF Family, Contributes to the Development of Choroidal NeovascularizationSemantic proximity Read ↗

Inhibition of Choroidal Neovascularization by Adenovirus-Mediated Delivery of Short Hairpin RNAs Targeting VEGF as a Potential Therapy for AMDSemantic proximity Read ↗

Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.