Article
Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).
Journal of thrombosis and haemostasis : JTH - 1 May 2005
Tsuchida-Straeten N, Ensslen S, Schäfer C, Wöltje M, Denecke B, Moser M, Gräber S, Wakabayashi S, Koide T, Jahnen-Dechent W
Abstract excerpt
Histidine-rich glycoprotein (HRG) is a serum protein belonging to the cystatin superfamily. HRG may play a regulatory role in hemostasis and innate immunity. However, this role is uncertain because of a lack of rigorous testing in an animal model. We generated mice lacking the translation start point of exon 1 of the Hrg gene, effectively resulting in a null mutation (Hrg-/-). The mice were viable and fertile but...
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