Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).

doi:10.1111/j.1538-7836.2005.01238.x

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Article

Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG).

Journal of thrombosis and haemostasis : JTH - 1 May 2005

Tsuchida-Straeten N, Ensslen S, Schäfer C, Wöltje M, Denecke B, Moser M, Gräber S, Wakabayashi S, Koide T, Jahnen-Dechent W

Abstract excerpt

Histidine-rich glycoprotein (HRG) is a serum protein belonging to the cystatin superfamily. HRG may play a regulatory role in hemostasis and innate immunity. However, this role is uncertain because of a lack of rigorous testing in an animal model. We generated mice lacking the translation start point of exon 1 of the Hrg gene, effectively resulting in a null mutation (Hrg-/-). The mice were viable and fertile but...

Topics

Animals
Bleeding Time
Blood Coagulation
Blood Platelets
Blotting, Southern
Cloning, Molecular
Exons
Fibrinolysis
Genetic Vectors
Genotype
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Models, Genetic

Molecular Sequence Data

Protein Binding

Proteins

Skin

Source

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Identifiers

PMID: 15869579
DOI: 10.1111/j.1538-7836.2005.01238.x

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