Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation.

doi:10.1016/0008-8749(92)90274-s

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Article

Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation.

Cellular immunology - 1 Jun 1992

Abo T, Kusumi A, Seki S, Ohteki T, Sugiura K, Masuda T, Rikiishi H, Iiai T, Kumagai K

Abstract excerpt

We recently demonstrated that the liver might be a major site of extrathymic T cell differentiation, including both alpha beta and gamma delta T cells. This extrathymic pathway in the liver, which has a relatively minor role in normal young mice, is activated in mice under bacterial stimulation. In the present study, we investigated how the extrathymic and intrathymic T cell differentiations were mutually related...

Topics

Animals
Atrophy
Cell Differentiation
Corticosterone
Escherichia coli
Hydrocortisone
Leukocyte Count
Leukocytes, Mononuclear
Liver
Lymphocyte Activation
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C3H

Phenotype

Spleen

T-Lymphocytes

Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 1586952
DOI: 10.1016/0008-8749(92)90274-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1586952-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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