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Article

p53-dependent inhibition of progestin-induced VEGF expression in human breast cancer cells.

The Journal of steroid biochemistry and molecular biology - 1 Feb 2005

Liang Yayun, Wu Jianbo, Stancel George M, Hyder Salman M

Abstract excerpt

VEGF, a potent angiogenic growth factor, is up-regulated in many tumors including human breast tumors and stimulates growth of vascular networks that support tumor growth and metastasis. We previously reported that natural and synthetic progestins (P) increased VEGF mRNA and protein levels in progesterone receptor (PR) containing T47-D human breast cancer cells in a PR dependent manner, but not in PR positive...

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Share to DNA, Neoplasm
Share to Genes, p53
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Hormone-Dependent

Share to Receptors, Estrogen

Share to Receptors, Progesterone

Share to Tumor Suppressor Protein p53

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 15860260
DOI: 10.1016/j.jsbmb.2004.12.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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