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Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β

19 Sept 2000

Abstract excerpt

Vascular endothelial growth factor (VEGF) mediates angiogenic activity in a variety of estrogen target tissues. To determine whether estrogen has a direct transcriptional effect on VEGF gene expression, we developed a model system by transiently transfecting human VEGF promoter-luciferase reporter constructs into primary human endometrial cells and into Ishikawa cells, derived from a well-differentiated human...

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PMID: 10995484
DOI: 10.1073/pnas.200377097

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