Article
Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants.
Journal of virology - 1 May 2005
Sui Jianhua, Li Wenhui, Roberts Anjeanette, Matthews Leslie J, Murakami Akikazu, Vogel Leatrice, Wong Swee Kee, Subbarao Kanta, Farzan Michael, Marasco Wayne A
Abstract excerpt
In this report, the antiviral activity of 80R immunoglobulin G1 (IgG1), a human monoclonal antibody against severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein that acts as a viral entry inhibitor in vitro, was investigated in vivo in a mouse model. When 80R IgG1 was given prophylactically to mice at doses therapeutically achievable in humans, viral replication was reduced by more than 4...
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